Composition des globines a et b de HbA et de HbS

  HbA   HbS

 

globines a

globines b

globines a

globines b
1 VAL VAL VAL VAL   VAL VAL VAL VAL
2 LEU LEU HIS HIS LEU LEU HIS HIS
3 SER SER LEU LEU SER SER LEU LEU
4 PRO PRO THR THR PRO PRO THR THR
5 ALA ALA PRO PRO ALA ALA PRO PRO
6 ASP ASP GLU GLU ASP ASP VAL VAL
7 LYS LYS GLU GLU LYS LYS GLU GLU
8 THR THR LYS LYS THR THR LYS LYS
9 ASN ASN SER SER ASN ASN SER SER
10 VAL VAL ALA ALA VAL VAL ALA ALA
11 LYS LYS VAL VAL LYS LYS VAL VAL
12 ALA ALA THR THR ALA ALA THR THR
13 ALA ALA ALA ALA ALA ALA ALA ALA
14 TRP TRP LEU LEU TRP TRP LEU LEU
15 GLY GLY TRP TRP GLY GLY TRP TRP
16 LYS LYS GLY GLY LYS LYS GLY GLY
17 VAL VAL LYS LYS VAL VAL LYS LYS
18 GLY GLY VAL VAL GLY GLY VAL VAL
19 ALA ALA ASN ASN ALA ALA ASN ASN
20 HIS HIS VAL VAL HIS HIS VAL VAL
21 ALA ALA ASP ASP ALA ALA ASP ASP
22 GLY GLY GLU GLU GLY GLY GLU GLU
23 GLU GLU VAL VAL GLU GLU VAL VAL
24 TYR TYR GLY GLY TYR TYR GLY GLY
25 GLY GLY GLY GLY GLY GLY GLY GLY
26 ALA ALA GLU GLU ALA ALA GLU GLU
27 GLU GLU ALA ALA GLU GLU ALA ALA
28 ALA ALA LEU LEU ALA ALA LEU LEU
29 LEU LEU GLY GLY LEU LEU GLY GLY
30 GLU GLU ARG ARG GLU GLU ARG ARG
31 ARG ARG LEU LEU ARG ARG LEU LEU
32 MET MET LEU LEU MET MET LEU LEU
33 PHE PHE VAL VAL PHE PHE VAL VAL
34 LEU LEU VAL VAL LEU LEU VAL VAL
35 SER SER TYR TYR SER SER TYR TYR
36 PHE PHE PRO PRO PHE PHE PRO PRO
37 PRO PRO ARG ARG PRO PRO ARG ARG
38 THR THR THR THR THR THR THR THR
39 THR THR GLN GLN THR THR GLN GLN
40 LYS LYS ARG ARG LYS LYS ARG ARG
41 THR THR PHE PHE THR THR PHE PHE
42 TYR TYR PHE PHE TYR TYR PHE PHE
43 PHE PHE GLU GLU PHE PHE GLU GLU
44 PRO PRO SER SER PRO PRO SER SER
45 HIS HIS PHE PHE HIS HIS PHE PHE
46 PHE PHE GLY GLY PHE PHE GLY GLY
47 ASP ASP ASP ASP ASP ASP ASP ASP
48 LEU LEU LEU LEU LEU LEU LEU LEU
49 SER SER SER SER SER SER SER SER
50 HIS HIS THR THR HIS HIS THR THR
51 GLY GLY PRO PRO GLY GLY PRO PRO
52 SER SER ASP ASP SER SER ASP ASP
53 ALA ALA ALA ALA ALA ALA ALA ALA
54 GLN GLN VAL VAL GLN GLN VAL VAL
55 VAL VAL MET MET VAL VAL MET MET
56 LYS LYS GLY GLY LYS LYS GLY GLY
57 GLY GLY ASN ASN GLY GLY ASN ASN
58 HIS HIS PRO PRO HIS HIS PRO PRO
59 GLY GLY LYS LYS GLY GLY LYS LYS
60 LYS LYS VAL VAL LYS LYS VAL VAL
61 LYS LYS LYS LYS LYS LYS LYS LYS
62 VAL VAL ALA ALA VAL VAL ALA ALA
63 ALA ALA HIS HIS ALA ALA HIS HIS
64 ASP ASP GLY GLY ASP ASP GLY GLY
65 ALA ALA LYS LYS ALA ALA LYS LYS
66 LEU LEU LYS LYS LEU LEU LYS LYS
67 THR THR VAL VAL THR THR VAL VAL
68 ASN ASN LEU LEU ASN ASN LEU LEU
69 ALA ALA GLY GLY ALA ALA GLY GLY
70 VAL VAL ALA ALA VAL VAL ALA ALA
71 ALA ALA PHE PHE ALA ALA PHE PHE
72 HIS HIS SER SER HIS HIS SER SER
73 VAL VAL ASP ASP VAL VAL ASP ASP
74 ASP ASP GLY GLY ASP ASP GLY GLY
75 ASP ASP LEU LEU ASP ASP LEU LEU
76 MET MET ALA ALA MET MET ALA ALA
77 PRO PRO HIS HIS PRO PRO HIS HIS
78 ASN ASN LEU LEU ASN ASN LEU LEU
79 ALA ALA ASP ASP ALA ALA ASP ASP
80 LEU LEU ASN ASN LEU LEU ASN ASN
81 SER SER LEU LEU SER SER LEU LEU
82 ALA ALA LYS LYS ALA ALA LYS LYS
83 LEU LEU GLY GLY LEU LEU GLY GLY
84 SER SER THR THR SER SER THR THR
85 ASP ASP PHE PHE ASP ASP PHE PHE
86 LEU LEU ALA ALA LEU LEU ALA ALA
87 HIS HIS THR THR HIS HIS THR THR
88 ALA ALA LEU LEU ALA ALA LEU LEU
89 HIS HIS SER SER HIS HIS SER SER
90 LYS LYS GLU GLU LYS LYS GLU GLU
91 LEU LEU LEU LEU LEU LEU LEU LEU
92 ARG ARG HIS HIS ARG ARG HIS HIS
93 VAL VAL CYS CYS VAL VAL CYS CYS
94 ASP ASP ASP ASP ASP ASP ASP ASP
95 PRO PRO LYS LYS PRO PRO LYS LYS
96 VAL VAL LEU LEU VAL VAL LEU LEU
97 ASN ASN HIS HIS ASN ASN HIS HIS
98 PHE PHE VAL VAL PHE PHE VAL VAL
99 LYS LYS ASP ASP LYS LYS ASP ASP
100 LEU LEU PRO PRO LEU LEU PRO PRO
101 LEU LEU GLU GLU LEU LEU GLU GLU
102 SER SER ASN ASN SER SER ASN ASN
103 HIS HIS PHE PHE HIS HIS PHE PHE
104 CYS CYS ARG ARG CYS CYS ARG ARG
105 LEU LEU LEU LEU LEU LEU LEU LEU
106 LEU LEU LEU LEU LEU LEU LEU LEU
107 VAL VAL GLY GLY VAL VAL GLY GLY
108 THR THR ASN ASN THR THR ASN ASN
109 LEU LEU VAL VAL LEU LEU VAL VAL
110 ALA ALA LEU LEU ALA ALA LEU LEU
111 ALA ALA VAL VAL ALA ALA VAL VAL
112 HIS HIS CYS CYS HIS HIS CYS CYS
113 LEU LEU VAL VAL LEU LEU VAL VAL
114 PRO PRO LEU LEU PRO PRO LEU LEU
115 ALA ALA ALA ALA ALA ALA ALA ALA
116 GLU GLU HIS HIS GLU GLU HIS HIS
117 PHE PHE HIS HIS PHE PHE HIS HIS
118 THR THR PHE PHE THR THR PHE PHE
119 PRO PRO GLY GLY PRO PRO GLY GLY
120 ALA ALA LYS LYS ALA ALA LYS LYS
121 VAL VAL GLU GLU VAL VAL GLU GLU
122 HIS HIS PHE PHE HIS HIS PHE PHE
123 ALA ALA THR THR ALA ALA THR THR
124 SER SER PRO PRO SER SER PRO PRO
125 LEU LEU PRO PRO LEU LEU PRO PRO
126 ASP ASP VAL VAL ASP ASP VAL VAL
127 LYS LYS GLN GLN LYS LYS GLN GLN
128 PHE PHE ALA ALA PHE PHE ALA ALA
129 LEU LEU ALA ALA LEU LEU ALA ALA
130 ALA ALA TYR TYR ALA ALA TYR TYR
131 SER SER GLN GLN SER SER GLN GLN
132 VAL VAL LYS LYS VAL VAL LYS LYS
133 SER SER VAL VAL SER SER VAL VAL
134 THR THR VAL VAL THR THR VAL VAL
135 VAL VAL ALA ALA VAL VAL ALA ALA
136 LEU LEU GLY GLY LEU LEU GLY GLY
137 THR THR VAL VAL THR THR VAL VAL
138 SER SER ALA ALA SER SER ALA ALA
139 LYS LYS ASN ASN LYS LYS ASN ASN
140 TYR TYR ALA ALA TYR TYR ALA ALA
141 ARG ARG LEU LEU ARG ARG LEU LEU
142     ALA ALA     ALA ALA
143     HIS HIS     HIS HIS
144     LYS LYS     LYS LYS
145     TYR TYR     TYR TYR
146     HIS HIS     HIS HIS
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